Can you provide more information about how this would look. A sketch showing both the mobie and the desktop views would make this easier to try to understand exactly what you are trying to do.
Splider can certainly display 1 slide with nav arrows either side. Also a Splider can be located inside a column and also a column can go inside a Splider Slide. Also you have full Flexbox alignment inside Splider to position your slide content where you want it.
As you are using Foundry, the display will be dictated by how you setup the 2 Column stack to behave.